GB1433151A - Benzo-ij-quinolizines - Google Patents

Benzo-ij-quinolizines

Info

Publication number
GB1433151A
GB1433151A GB1627973A GB1627973A GB1433151A GB 1433151 A GB1433151 A GB 1433151A GB 1627973 A GB1627973 A GB 1627973A GB 1627973 A GB1627973 A GB 1627973A GB 1433151 A GB1433151 A GB 1433151A
Authority
GB
United Kingdom
Prior art keywords
benzo
quinolizine
dihydro
oxo
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1627973A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Priority to GB1627973A priority Critical patent/GB1433151A/en
Priority to ZA00741860A priority patent/ZA741860B/xx
Priority to IE649/74A priority patent/IE39101B1/xx
Priority to US455071A priority patent/US3917608A/en
Priority to AU67200/74A priority patent/AU6720074A/en
Priority to DE2415763A priority patent/DE2415763A1/de
Priority to BE142731A priority patent/BE813158A/xx
Priority to LU69756A priority patent/LU69756A1/xx
Priority to CH462974A priority patent/CH602722A5/xx
Priority to AT277074A priority patent/AT330180B/de
Priority to FR7411776A priority patent/FR2230355B1/fr
Priority to NL7404719A priority patent/NL7404719A/xx
Priority to CA197,107A priority patent/CA1015758A/en
Priority to JP49039368A priority patent/JPS5024296A/ja
Publication of GB1433151A publication Critical patent/GB1433151A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB1627973A 1973-04-05 1973-04-05 Benzo-ij-quinolizines Expired GB1433151A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB1627973A GB1433151A (en) 1973-04-05 1973-04-05 Benzo-ij-quinolizines
ZA00741860A ZA741860B (en) 1973-04-05 1974-03-21 Heterocyclic compounds
IE649/74A IE39101B1 (en) 1973-04-05 1974-03-25 Benzo (ij) quinolizines
US455071A US3917608A (en) 1973-04-05 1974-03-27 Substituted 6,7 dihydro-1-oxo N(1H-tetrazol-5-yl)-1H,5H-benzo{8 ij{9 quinolizine carboxamides
AU67200/74A AU6720074A (en) 1973-04-05 1974-03-27 Heterocyclic compounds
DE2415763A DE2415763A1 (de) 1973-04-05 1974-04-01 Neue benzochinolizine, verfahren zu ihrer herstellung und diese enthaltende mittel
BE142731A BE813158A (fr) 1973-04-05 1974-04-01 Nouvelles benzoquinolizines
LU69756A LU69756A1 (en]) 1973-04-05 1974-04-01
CH462974A CH602722A5 (en]) 1973-04-05 1974-04-02
AT277074A AT330180B (de) 1973-04-05 1974-04-03 Verfahren zur herstellung von neuen benzo-(ij)-chinolizinderivaten und ihren salzen
FR7411776A FR2230355B1 (en]) 1973-04-05 1974-04-03
NL7404719A NL7404719A (en]) 1973-04-05 1974-04-05
CA197,107A CA1015758A (en) 1973-04-05 1974-04-05 6,7-dihydro-1-oxo-n(1h-tetrazol-5-yl)-1h,5h-benzo(ij)quinolizine-2-carboxamides
JP49039368A JPS5024296A (en]) 1973-04-05 1974-04-05

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1627973A GB1433151A (en) 1973-04-05 1973-04-05 Benzo-ij-quinolizines

Publications (1)

Publication Number Publication Date
GB1433151A true GB1433151A (en) 1976-04-22

Family

ID=10074459

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1627973A Expired GB1433151A (en) 1973-04-05 1973-04-05 Benzo-ij-quinolizines

Country Status (14)

Country Link
US (1) US3917608A (en])
JP (1) JPS5024296A (en])
AT (1) AT330180B (en])
AU (1) AU6720074A (en])
BE (1) BE813158A (en])
CA (1) CA1015758A (en])
CH (1) CH602722A5 (en])
DE (1) DE2415763A1 (en])
FR (1) FR2230355B1 (en])
GB (1) GB1433151A (en])
IE (1) IE39101B1 (en])
LU (1) LU69756A1 (en])
NL (1) NL7404719A (en])
ZA (1) ZA741860B (en])

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0157346A3 (en) * 1984-03-30 1986-02-05 Fujisawa Pharmaceutical Co., Ltd. Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same
WO1997031000A1 (en) * 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones and their therapeutic use
WO1997030999A1 (en) * 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones and their therapeutic use
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
RU2204553C2 (ru) * 1997-03-10 2003-05-20 Янссен Фармацевтика Н.В. 1,8-аннелированные производные хинолинона, замещенные n- или c-связанными имидазолами, ингибирующие фарнезилтрансферазу

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051247A (en) * 1975-04-14 1977-09-27 Riker Laboratories, Inc. Method of using 7-hydroxy-benzo[ij]quinolizine-2-carboxylic acid derivatives
AT377986B (de) * 1978-08-31 1985-05-28 Otsuka Pharma Co Ltd Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen
JPS5540616A (en) * 1978-09-14 1980-03-22 Otsuka Pharmaceut Co Ltd Preparation of benzo-hetero-compound
AT377987B (de) * 1979-04-11 1985-05-28 Otsuka Pharma Co Ltd Verfahren zur herstellung von neuen piperazinylbenzoheterozyklischen verbindungen und ihren pharmazeutisch annehmbaren salzen
US4400386A (en) * 1981-11-06 1983-08-23 Riker Laboratories, Inc. Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine
US4472407A (en) * 1983-03-17 1984-09-18 Riker Laboratories, Inc. Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu
CA1266484A (en) * 1984-12-14 1990-03-06 Ronald Edward Mac Leay Tert-octylhydrazine, its salts and derivatives
DE3519926A1 (de) * 1985-06-04 1986-12-04 Bayer Ag Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
ES2656017T3 (es) 2004-06-24 2018-02-22 Vertex Pharmaceuticals Incorporated Moduladores de transportadores del casete de unión a ATP
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
EP2502912A3 (en) * 2004-06-24 2013-11-06 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
RU2556984C2 (ru) * 2004-06-24 2015-07-20 Вертекс Фармасьютикалз Инкорпорейтед Модуляторы транспортеров атф-связывающей кассеты
HUE049976T2 (hu) 2005-12-28 2020-11-30 Vertex Pharma N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói
KR101955863B1 (ko) 2009-03-20 2019-03-07 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
EP2819670A1 (en) 2012-02-27 2015-01-07 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
MX370450B (es) 2014-10-07 2019-12-13 Vertex Pharma Co-cristales de moduladores de regulador de conductancia de transmembrana en fibrosis quistica.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728350A (en) * 1967-07-17 1973-04-17 Lilly Co Eli 1-(2-carboxyphenyl)-5,7-dimethoxy-3,4-dihydrocarbostyril intermediates for acronycis
US3793328A (en) * 1969-11-03 1974-02-19 Upjohn Co 8benzoyl 1,2,3,4 tetrahydroquinoline
BE789822A (fr) * 1971-10-08 1973-04-06 Allen & Hanburys Ltd Nouveaux composes heterocycliques
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0157346A3 (en) * 1984-03-30 1986-02-05 Fujisawa Pharmaceutical Co., Ltd. Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same
WO1997031000A1 (en) * 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones and their therapeutic use
WO1997030999A1 (en) * 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones and their therapeutic use
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
RU2204553C2 (ru) * 1997-03-10 2003-05-20 Янссен Фармацевтика Н.В. 1,8-аннелированные производные хинолинона, замещенные n- или c-связанными имидазолами, ингибирующие фарнезилтрансферазу

Also Published As

Publication number Publication date
FR2230355B1 (en]) 1977-05-06
DE2415763A1 (de) 1974-10-17
ZA741860B (en) 1975-02-26
FR2230355A1 (en]) 1974-12-20
AU474838B2 (en]) 1976-08-05
AU6720074A (en) 1975-10-02
AT330180B (de) 1976-06-25
ATA277074A (de) 1975-09-15
IE39101L (en) 1974-10-05
US3917608A (en) 1975-11-04
BE813158A (fr) 1974-10-01
CA1015758A (en) 1977-08-16
IE39101B1 (en) 1978-08-02
LU69756A1 (en]) 1975-06-16
JPS5024296A (en]) 1975-03-15
NL7404719A (en]) 1974-10-08
CH602722A5 (en]) 1978-07-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee